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Comparative Analysis of Viperidae Venoms Antibacterial Profile : a Short Communication for Proteomics
Joint Authors
Cabral, Lúcio M.
Santos, André Luis dos
Santos, Dilvani O.
Rodrigues, Carlos R.
Ferreira, Bruno L.
de Freitas, Cícero C.
Castro, Helena C.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-05
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Bacterial infections involving multidrug-resistant strains are one of the ten leading causes of death and an important health problem in need for new antibacterial sources and agents.
Herein, we tested and compared four snake venoms (Agkistrodon rhodostoma, Bothrops jararaca, B.
atrox and Lachesis muta) against 10 Gram-positive and Gram-negative drug-resistant clinical bacteria strains to identify them as new sources of potential antibacterial molecules.
Our data revealed that, as efficient as some antibiotics currently on the market (minimal inhibitory concentration (MIC) = 1–32 μg mL−1), A.
rhodostoma and B.
atrox venoms were active against Staphylococcus epidermidis and Enterococcus faecalis (MIC = 4.5 μg mL−1), while B.
jararaca inhibited S.
aureus growth (MIC = 13 μg ml−1).
As genomic and proteomic technologies are improving and developing rapidly, our results suggested that A.
rhodostoma, B.
atrox and B.
jararaca venoms and glands are feasible sources for searching antimicrobial prototypes for future design new antibiotics against drug-resistant clinical bacteria.
They also point to an additional perspective to fully identify the pharmacological potential of these venoms by using different techniques.
American Psychological Association (APA)
Ferreira, Bruno L.& Santos, Dilvani O.& Santos, André Luis dos& Rodrigues, Carlos R.& de Freitas, Cícero C.& Cabral, Lúcio M.…[et al.]. 2011. Comparative Analysis of Viperidae Venoms Antibacterial Profile : a Short Communication for Proteomics. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-511574
Modern Language Association (MLA)
Ferreira, Bruno L.…[et al.]. Comparative Analysis of Viperidae Venoms Antibacterial Profile : a Short Communication for Proteomics. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-511574
American Medical Association (AMA)
Ferreira, Bruno L.& Santos, Dilvani O.& Santos, André Luis dos& Rodrigues, Carlos R.& de Freitas, Cícero C.& Cabral, Lúcio M.…[et al.]. Comparative Analysis of Viperidae Venoms Antibacterial Profile : a Short Communication for Proteomics. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-511574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511574