METHGF Signaling Pathway in Ovarian Carcinoma : Clinical Implications and Future Direction
Joint Authors
Mhawech-Fauceglia, Paulette
Afkhami, Michelle
Pejovic, Tanja
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The HGF/MET signaling pathway is abnormal in numerous cancers including ovarian cancer.
MET is expressed in 70% of human cancer and it is overexpressed in 30% of ovarian cases and cancer cell lines.
The HGF/MET pathway plays a role in the initiation and progression of ovarian cancer through the most distinctive biologic program known as “invasive growth” which is accomplished through a coordinated activation of cell motility, invasiveness, degradation of extracellular matrix, survival, and proliferation.
Because of its ubiquitous role in cancer, the MET axis seems to be an attractive target for cancer therapy.
Numerous HGF/MET pathway inhibitor compounds are already in use in clinical trials in various solid tumors.
In this paper, we will discuss the HGF/MET pathway in ovarian cancer, its clinical significance, and its potential use as a target therapy in the future.
American Psychological Association (APA)
Mhawech-Fauceglia, Paulette& Afkhami, Michelle& Pejovic, Tanja. 2012. METHGF Signaling Pathway in Ovarian Carcinoma : Clinical Implications and Future Direction. Pathology Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511582
Modern Language Association (MLA)
Mhawech-Fauceglia, Paulette…[et al.]. METHGF Signaling Pathway in Ovarian Carcinoma : Clinical Implications and Future Direction. Pathology Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-511582
American Medical Association (AMA)
Mhawech-Fauceglia, Paulette& Afkhami, Michelle& Pejovic, Tanja. METHGF Signaling Pathway in Ovarian Carcinoma : Clinical Implications and Future Direction. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511582