![](/images/graphics-bg.png)
Improving Hepatitis B Vaccine Efficacy in End-Stage Renal Diseases Patients and Role of Adjuvants
Joint Authors
Hajipour, Babak
Sumi, Muhammad Husayn
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hepatitis B virus (HBV) infection is a serious global health problem.The prevalence of viral hepatitis is higher in dialysis patients than in the general population because of the opportunity for exposure during the dialysis procedure.
Immunization is the most effective way to prevent transmission of hepatitis B virus (HBV) and hence the development of acute or chronic hepatitis B.
It is well established that patients with end-stage renal disease including dialysis-dependent patients, have an impaired immune response to hepatitis B vaccine.
End stage renal diseases (ESRD) patients have lower seroconversion rates compared with the subjects with intact renal function.
Moreover, even after the completion of vaccination schedule anti-hepatitis B (anti-HBs) titers of responder dialysis, patients are low and decline logarithmically with time.
The impaired efficacy of HBV vaccine in patients with ESRD has been attributed to numerous factors such as immune compromise because of uremia and some other factors.
One approach to improve the immunogenicity of existing HBV vaccines is adjuvantation, and it's very important to find more effective adjutants for improving HBV vaccine efficacy.
In this paper we have a brief review on recently known new ways for improving HBV vaccine efficacy.
American Psychological Association (APA)
Sumi, Muhammad Husayn& Hajipour, Babak. 2012. Improving Hepatitis B Vaccine Efficacy in End-Stage Renal Diseases Patients and Role of Adjuvants. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511587
Modern Language Association (MLA)
Sumi, Muhammad Husayn& Hajipour, Babak. Improving Hepatitis B Vaccine Efficacy in End-Stage Renal Diseases Patients and Role of Adjuvants. ISRN Gastroenterology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-511587
American Medical Association (AMA)
Sumi, Muhammad Husayn& Hajipour, Babak. Improving Hepatitis B Vaccine Efficacy in End-Stage Renal Diseases Patients and Role of Adjuvants. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511587