The Distribution of eIF4E-Family Members across Insecta
Joint Authors
Hernández, Greco
Lasko, Paul
Kowanda, Michelle
Sonenberg, Nahum
Tettweiler, Gritta
Source
Comparative and Functional Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-13
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Insects are part of the earliest faunas that invaded terrestrial environments and are the first organisms that evolved controlled flight.
Nowadays, insects are the most diverse animal group on the planet and comprise the majority of extant animal species described.
Moreover, they have a huge impact in the biosphere as well as in all aspects of human life and economy; therefore understanding all aspects of insect biology is of great importance.
In insects, as in all cells, translation is a fundamental process for gene expression.
However, translation in insects has been mostly studied only in the model organism Drosophila melanogaster.
We used all publicly available genomic sequences to investigate in insects the distribution of the genes encoding the cap-binding protein eIF4E, a protein that plays a crucial role in eukaryotic translation.
We found that there is a diversity of multiple ortholog genes encoding eIF4E isoforms within the genus Drosophila.
In striking contrast, insects outside this genus contain only a single eIF4E gene, related to D.
melanogaster eIF4E-1.
We also found that all insect species here analyzed contain only one Class II gene, termed 4E-HP.
We discuss the possible evolutionary causes originating the multiplicity of eIF4E genes within the genus Drosophila.
American Psychological Association (APA)
Tettweiler, Gritta& Kowanda, Michelle& Lasko, Paul& Sonenberg, Nahum& Hernández, Greco. 2012. The Distribution of eIF4E-Family Members across Insecta. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-511588
Modern Language Association (MLA)
Tettweiler, Gritta…[et al.]. The Distribution of eIF4E-Family Members across Insecta. Comparative and Functional Genomics No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-511588
American Medical Association (AMA)
Tettweiler, Gritta& Kowanda, Michelle& Lasko, Paul& Sonenberg, Nahum& Hernández, Greco. The Distribution of eIF4E-Family Members across Insecta. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-511588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511588