Comparative Study on the Effects of Chloroquine and Artesunate on Histopathological Damages Caused by Plasmodium berghei in Four Vital Organs of Infected Albino Mice
Joint Authors
Idowu, O. A.
Ajayi, O. L.
Olubi, I. C.
Soniran, O. T.
Source
Malaria Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of the present study was to investigate the positive influence of chloroquine and artesunate on the pathological damages caused by Plasmodium berghei on vital organs of mice in an established infection.
Healthy adult albino mice with average weight of 25 g were used for the study.
Treated group was administered orally with 100 mg/kg of chloroquine and artesunate, respectively.
Control animals were given water for the same period.
Histological examination of the liver, spleen, lungs, and kidney revealed absence of accumulation of iron (haemosiderosis) in the liver, thickened alveolar wall, and interstitial mononuclear cells infiltration in the lungs of the artesunate group, while absence of emphysema in the lungs and megakaryoblast hyperplasia in the spleen was observed in the chloroquine group.
Lymphoid hypoplasia in the chloroquine group and megakayoblast hyperplasia in the artesunate group were observed but not in the control group.
Thus, the use of these drugs especially under the practice of self-medication should be prohibited in lands where they are still in use as antimalaria medicine.
American Psychological Association (APA)
Soniran, O. T.& Idowu, O. A.& Ajayi, O. L.& Olubi, I. C.. 2012. Comparative Study on the Effects of Chloroquine and Artesunate on Histopathological Damages Caused by Plasmodium berghei in Four Vital Organs of Infected Albino Mice. Malaria Research and Treatment،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511618
Modern Language Association (MLA)
Soniran, O. T.…[et al.]. Comparative Study on the Effects of Chloroquine and Artesunate on Histopathological Damages Caused by Plasmodium berghei in Four Vital Organs of Infected Albino Mice. Malaria Research and Treatment No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-511618
American Medical Association (AMA)
Soniran, O. T.& Idowu, O. A.& Ajayi, O. L.& Olubi, I. C.. Comparative Study on the Effects of Chloroquine and Artesunate on Histopathological Damages Caused by Plasmodium berghei in Four Vital Organs of Infected Albino Mice. Malaria Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511618