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QT Measurement and Heart Rate Correction during Hypoglycemia : Is There a Bias?
Joint Authors
Randløv, Jette
Eldrup, Ebbe
Kristensen, Leif Engmann
Christensen, Toke Folke
Struijk, Johannes Jan
Hejlesen, Ole Kristian
Source
Cardiology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Several studies show that hypoglycemia causes QT interval prolongation.
The aim of this study was to investigate the effect of QT measurement methodology, heart rate correction, and insulin types during hypoglycemia.
Methods.
Ten adult subjects with type 1 diabetes had hypoglycemia induced by intravenous injection of two insulin types in a cross-over design.
QT measurements were done using the slope-intersect (SI) and manual annotation (MA) methods.
Heart rate correction was done using Bazett’s (QTcB) and Fridericia’s (QTcF) formulas.
Results.
The SI method showed significant prolongation at hypoglycemia for QTcB (42(6) ms; P<.001) and QTcF (35(6) ms; P<.001).
The MA method showed prolongation at hypoglycemia for QTcB (7(2) ms, P<.05) but not QTcF.
No difference in ECG variables between the types of insulin was observed.
Discussion.
The method for measuring the QT interval has a significant impact on the prolongation of QT during hypoglycemia.
Heart rate correction may also influence the QT during hypoglycemia while the type of insulin is insignificant.
Prolongation of QTc in this study did not reach pathologic values suggesting that QTc prolongation cannot fully explain the dead-in-bed syndrome.
American Psychological Association (APA)
Christensen, Toke Folke& Randløv, Jette& Kristensen, Leif Engmann& Eldrup, Ebbe& Hejlesen, Ole Kristian& Struijk, Johannes Jan. 2010. QT Measurement and Heart Rate Correction during Hypoglycemia : Is There a Bias?. Cardiology Research and Practice،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-511664
Modern Language Association (MLA)
Christensen, Toke Folke…[et al.]. QT Measurement and Heart Rate Correction during Hypoglycemia : Is There a Bias?. Cardiology Research and Practice No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-511664
American Medical Association (AMA)
Christensen, Toke Folke& Randløv, Jette& Kristensen, Leif Engmann& Eldrup, Ebbe& Hejlesen, Ole Kristian& Struijk, Johannes Jan. QT Measurement and Heart Rate Correction during Hypoglycemia : Is There a Bias?. Cardiology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-511664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511664