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Assessment of Metformin as an Additional Treatment to Therapeutic Lifestyle Changes in Pediatric Patients with Metabolic Syndrome
Joint Authors
Raub, Rebecca M.
Goldberg, Stanley J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To assess the effectiveness of metformin and therapeutic lifestyle changes (TLCs) in a clinical setting, compared to TLC alone in adolescents with metabolic syndrome (MS).
Methodology.
This study was a retrospective trial consisting of 60 patients, aged 8–18 years, who were treated for MS at an outpatient clinic.
Two groups were formed: the metformin group (M group) and the control group (C group).
The M group had been given metformin along with TLC, and the C group had been given TLC alone.
Several outcome measures were obtained; the main outcome measure was measuring the change in percentile and z-score of weight and BMI.
Results.
There were no significant differences between the two groups at the conclusion of the study, except for height percentile (P=0.02) and z-score (P=0.03).
Both groups showed promising significant intragroup decreases in weight z-score but BMI percentile and z-score were only significantly decreased in the M group.
Conclusion.
Metformin at an average dose of 1033 mg, when added to TLC, did not show any clinically important efficacy compared to TLC alone in a pediatric population with MS.
However, both groups made significant changes in a positive direction, which may be solely due to TLC.
American Psychological Association (APA)
Raub, Rebecca M.& Goldberg, Stanley J.. 2012. Assessment of Metformin as an Additional Treatment to Therapeutic Lifestyle Changes in Pediatric Patients with Metabolic Syndrome. Cholesterol،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-511677
Modern Language Association (MLA)
Raub, Rebecca M.& Goldberg, Stanley J.. Assessment of Metformin as an Additional Treatment to Therapeutic Lifestyle Changes in Pediatric Patients with Metabolic Syndrome. Cholesterol No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-511677
American Medical Association (AMA)
Raub, Rebecca M.& Goldberg, Stanley J.. Assessment of Metformin as an Additional Treatment to Therapeutic Lifestyle Changes in Pediatric Patients with Metabolic Syndrome. Cholesterol. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-511677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511677