Understanding Cellular Mechanisms Underlying Airway Epithelial Repair : Selecting the Most Appropriate Animal Models
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Understanding the mechanisms underlying the process of regeneration and repair of airway epithelial structures demands close characterization of the associated cellular and molecular events.
The choice of an animal model system to study these processes and the role of lung stem cells is debatable since ideally the chosen animal model should offer a valid comparison with the human lung.
Species differences may include the complex three-dimensional lung structures, cellular composition of the lung airway as well as transcriptional control of the molecular events in response to airway epithelium regeneration, and repair following injury.
In this paper, we discuss issues related to the study of the lung repair and regeneration including the role of putative stem cells in small- and large-animal models.
At the end of this paper, the author discuss the potential for using sheep as a model which can help bridge the gap between small-animal model systems and humans.
American Psychological Association (APA)
Yahaya, B.. 2012. Understanding Cellular Mechanisms Underlying Airway Epithelial Repair : Selecting the Most Appropriate Animal Models. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-511706
Modern Language Association (MLA)
Yahaya, B.. Understanding Cellular Mechanisms Underlying Airway Epithelial Repair : Selecting the Most Appropriate Animal Models. The Scientific World Journal No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-511706
American Medical Association (AMA)
Yahaya, B.. Understanding Cellular Mechanisms Underlying Airway Epithelial Repair : Selecting the Most Appropriate Animal Models. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-511706
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511706