Development of Mass Spectrometry Selected Reaction Monitoring Method for Quantitation and Pharmacokinetic Study of Stepharine in Rabbit Plasma
Joint Authors
Kuznetsova, Ksenia G.
Kopylov, Arthur T.
Alimov, Andrei A.
Moshkin, Andrey G.
Mikhailova, Olga M.
Turkin, Vladimir V.
Source
Advances in Pharmacological Sciences
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Highly sensitive liquid chromatography mass spectrometry method on triple quadrupole (QQQ) mass spectrometer was successfully applied for pharmacokinetic study of stepharine in rabbit plasma.
Specific ion transitions of stepharine protonated precursor ion were selected and recorded in the certain retention time employing dynamic selected reaction monitoring mode.
The developed method facilitated quantitative measurements of stepharine in plasma samples in linear range of five orders of magnitude with high accuracy and low standard deviation coefficient and pharmacokinetics parameters were calculated.
The apparent volume of stepharine distribution (estimated as ratio of clearance to elimination rate constant, data not shown) allows us to assume that stepharine was extensively distributed throughout the body.
American Psychological Association (APA)
Kopylov, Arthur T.& Kuznetsova, Ksenia G.& Mikhailova, Olga M.& Moshkin, Andrey G.& Turkin, Vladimir V.& Alimov, Andrei A.. 2014. Development of Mass Spectrometry Selected Reaction Monitoring Method for Quantitation and Pharmacokinetic Study of Stepharine in Rabbit Plasma. Advances in Pharmacological Sciences،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-511726
Modern Language Association (MLA)
Kopylov, Arthur T.…[et al.]. Development of Mass Spectrometry Selected Reaction Monitoring Method for Quantitation and Pharmacokinetic Study of Stepharine in Rabbit Plasma. Advances in Pharmacological Sciences No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-511726
American Medical Association (AMA)
Kopylov, Arthur T.& Kuznetsova, Ksenia G.& Mikhailova, Olga M.& Moshkin, Andrey G.& Turkin, Vladimir V.& Alimov, Andrei A.. Development of Mass Spectrometry Selected Reaction Monitoring Method for Quantitation and Pharmacokinetic Study of Stepharine in Rabbit Plasma. Advances in Pharmacological Sciences. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-511726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511726