![](/images/graphics-bg.png)
Oncogenic Alternative Splicing Switches : Role in Cancer Progression and Prospects for Therapy
Joint Authors
Catillo, Morena
Pignataro, Daniela
Bonomi, Serena
Biamonti, Giuseppe
Ghigna, Claudia
Gallo, Stefania
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Alterations in the abundance or activities of alternative splicing regulators generate alternatively spliced variants that contribute to multiple aspects of tumor establishment, progression and resistance to therapeutic treatments.
Notably, many cancer-associated genes are regulated through alternative splicing suggesting a significant role of this post-transcriptional regulatory mechanism in the production of oncogenes and tumor suppressors.
Thus, the study of alternative splicing in cancer might provide a better understanding of the malignant transformation and identify novel pathways that are uniquely relevant to tumorigenesis.
Understanding the molecular underpinnings of cancer-associated alternative splicing isoforms will not only help to explain many fundamental hallmarks of cancer, but will also offer unprecedented opportunities to improve the efficacy of anti-cancer treatments.
American Psychological Association (APA)
Bonomi, Serena& Gallo, Stefania& Catillo, Morena& Pignataro, Daniela& Biamonti, Giuseppe& Ghigna, Claudia. 2013. Oncogenic Alternative Splicing Switches : Role in Cancer Progression and Prospects for Therapy. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-511740
Modern Language Association (MLA)
Bonomi, Serena…[et al.]. Oncogenic Alternative Splicing Switches : Role in Cancer Progression and Prospects for Therapy. International Journal of Cell Biology No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-511740
American Medical Association (AMA)
Bonomi, Serena& Gallo, Stefania& Catillo, Morena& Pignataro, Daniela& Biamonti, Giuseppe& Ghigna, Claudia. Oncogenic Alternative Splicing Switches : Role in Cancer Progression and Prospects for Therapy. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-511740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511740