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Brain Natriuretic Peptide Production and Secretion in Inflammation
Joint Authors
de Bold, Adolfo J.
Ogawa, Tsuneo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Gene expression and secretion of the cardiac polypeptide hormones atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) are simultaneously upregulated in various cardiac disorders such as congestive heart failure, ischemic heart disease, and hypertensive heart disease, in which hemodynamic or neuroendocrine changes are key components in the progression of disease.
However, during acute cardiac allograft rejection, plasma BNP levels are increased but not those of ANF.
Successful treatment of the rejection episode decreases the elevated plasma BNP to prerejection values suggesting that substances related to inflammation may selectively influence BNP gene expression.
Indeed, cytokines such as TNFα and IL-1β selectively stimulate cardiac BNP at the transcriptional and translational levels in cardiomyocyte cultures without affecting ANF.
This selective BNP increase is seen in vivo, in addition to acute cardiac allograft rejection, in several circumstances where inflammation significantly contributes to the pathogenesis of disease such as in sepsis and in acute myocarditis.
American Psychological Association (APA)
Ogawa, Tsuneo& de Bold, Adolfo J.. 2012. Brain Natriuretic Peptide Production and Secretion in Inflammation. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511764
Modern Language Association (MLA)
Ogawa, Tsuneo& de Bold, Adolfo J.. Brain Natriuretic Peptide Production and Secretion in Inflammation. Journal of Transplantation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-511764
American Medical Association (AMA)
Ogawa, Tsuneo& de Bold, Adolfo J.. Brain Natriuretic Peptide Production and Secretion in Inflammation. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-511764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511764