Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection
Joint Authors
Caliari, Marcelo Vidigal
Wilson, R. Alan
Assis, Natan R. G.
Martins, Vicente P.
Morais, Suellen B.
Figueiredo, Bárbara C. P.
Castro-Borges, William
Azevedo, Vasco
Pinheiro, Carina S.
Oliveira, Sergio Costa
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The flatworm Schistosoma mansoni is a blood fluke parasite that causes schistosomiasis, a debilitating disease that occurs throughout the developing world.
Current schistosomiasis control strategies are mainly based on chemotherapy, but many researchers believe that the best long-term strategy to control schistosomiasis is through immunization with an antischistosomiasis vaccine combined with drug treatment.
In the search for potential vaccine candidates, numerous tegument antigens have been assessed.
As the major interface between parasite and mammalian host, the tegument plays crucial roles in the establishment and further course of schistosomiasis.
Herein, we evaluated the potential of a GPI fraction, containing representative molecules located on the outer surface of adult worms, as vaccine candidate.
Immunization of mice with GPI-anchored proteins induced a mixed Th1/Th2 type of immune response with production of IFN-γ and TNF-α, and low levels of IL-5 into the supernatant of splenocyte cultures.
The protection engendered by this vaccination protocol was confirmed by 42% reduction in worm burden, 45% reduction in eggs per gram of hepatic tissue, 29% reduction in the number of granulomas per area, and 53% reduction in the granuloma fibrosis.
Taken together, the data herein support the potential of surface-exposed GPI-anchored antigens from the S.
mansoni tegument as vaccine candidate.
American Psychological Association (APA)
Martins, Vicente P.& Pinheiro, Carina S.& Figueiredo, Bárbara C. P.& Assis, Natan R. G.& Morais, Suellen B.& Caliari, Marcelo Vidigal…[et al.]. 2012. Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-511780
Modern Language Association (MLA)
Martins, Vicente P.…[et al.]. Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection. Clinical and Developmental Immunology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-511780
American Medical Association (AMA)
Martins, Vicente P.& Pinheiro, Carina S.& Figueiredo, Bárbara C. P.& Assis, Natan R. G.& Morais, Suellen B.& Caliari, Marcelo Vidigal…[et al.]. Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-511780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511780