Link between Cancer and Alzheimer Disease via Oxidative Stress Induced by Nitric Oxide-Dependent Mitochondrial DNA Overproliferation and Deletion

Joint Authors

Aliev, Gjumrakch
Kamal, Mohammad Amjad
Reddy, V. Prakash
Li, Yi
Burnstock, Geoffrey
Tabrez, Shams
Cacabelos, Ramón
Jabir, Nasimudeen R.
Obrenovich, Mark E.

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-04-03

Country of Publication

Egypt

No. of Pages

19

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Biology

Abstract EN

Nitric oxide- (NO-) dependent oxidative stress results in mitochondrial ultrastructural alterations and DNA damage in cases of Alzheimer disease (AD).

However, little is known about these pathways in human cancers, especially during the development as well as the progression of primary brain tumors and metastatic colorectal cancer.

One of the key features of tumors is the deficiency in tissue energy that accompanies mitochondrial lesions and formation of the hypoxic smaller sized mitochondria with ultrastructural abnormalities.

We speculate that mitochondrial involvement may play a significant role in the etiopathogenesis of cancer.

Recent studies also demonstrate a potential link between AD and cancer, and anticancer drugs are being explored for the inhibition of AD-like pathology in transgenic mice.

Severity of the cancer growth, metastasis, and brain pathology in AD (in animal models that mimic human AD) correlate with the degree of mitochondrial ultrastructural abnormalities.

Recent advances in the cell-cycle reentry of the terminally differentiated neuronal cells indicate that NO-dependent mitochondrial abnormal activities and mitotic cell division are not the only important pathogenic factors in pathogenesis of cancer and AD, but open a new window for the development of novel treatment strategies for these devastating diseases.

American Psychological Association (APA)

Aliev, Gjumrakch& Obrenovich, Mark E.& Tabrez, Shams& Jabir, Nasimudeen R.& Reddy, V. Prakash& Li, Yi…[et al.]. 2013. Link between Cancer and Alzheimer Disease via Oxidative Stress Induced by Nitric Oxide-Dependent Mitochondrial DNA Overproliferation and Deletion. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-511826

Modern Language Association (MLA)

Aliev, Gjumrakch…[et al.]. Link between Cancer and Alzheimer Disease via Oxidative Stress Induced by Nitric Oxide-Dependent Mitochondrial DNA Overproliferation and Deletion. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-511826

American Medical Association (AMA)

Aliev, Gjumrakch& Obrenovich, Mark E.& Tabrez, Shams& Jabir, Nasimudeen R.& Reddy, V. Prakash& Li, Yi…[et al.]. Link between Cancer and Alzheimer Disease via Oxidative Stress Induced by Nitric Oxide-Dependent Mitochondrial DNA Overproliferation and Deletion. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-511826

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-511826