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A Combination of Systemic and Intracranial Anti-CD25 Immunotherapy Elicits a Long-Time Survival in Murine Model of Glioma
Joint Authors
El Andaloussi, Abdeljabar
Haban, Houda
Poirier, Marie-Denise
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Abrogating the suppression of glioma-infiltrating Tregs in the periphery and the central nervous system is essential to successful glioma rejection.
We sought to improve the immune response in glioma-bearing mice, by investigating new strategies using the anti-CD25 immunotherapy.
We found a complete long-term survival of glioma-bearing mice treated with a combination of systemic and intracranial anti-CD25 mAb immunotherapy as compared to systemic administration of anti-CD25 mAb.
In addition, the group of mice that had been cured by the combined anti-CD25 mAb showed long-term survival without late tumor relapse when challenged with the GL261 glioma.
The antitumor immune response was investigated by analysis of antitumor immune response (CTL).
Results showed that the use of the combined injections of anti-CD25 mAb induced efficient targeting of Tregs expansion inside and outside of the brain and altered Tregs trafficking in the bone marrow and brain areas where antitumor immunity was primed.
American Psychological Association (APA)
Poirier, Marie-Denise& Haban, Houda& El Andaloussi, Abdeljabar. 2010. A Combination of Systemic and Intracranial Anti-CD25 Immunotherapy Elicits a Long-Time Survival in Murine Model of Glioma. Journal of Oncology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-511828
Modern Language Association (MLA)
Poirier, Marie-Denise…[et al.]. A Combination of Systemic and Intracranial Anti-CD25 Immunotherapy Elicits a Long-Time Survival in Murine Model of Glioma. Journal of Oncology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-511828
American Medical Association (AMA)
Poirier, Marie-Denise& Haban, Houda& El Andaloussi, Abdeljabar. A Combination of Systemic and Intracranial Anti-CD25 Immunotherapy Elicits a Long-Time Survival in Murine Model of Glioma. Journal of Oncology. 2010. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-511828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511828