Nedaplatin : A Radiosensitizing Agent for Patients with Cervical Cancer
Joint Authors
Source
Chemotherapy Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Despite the recent advances in the management of cervical cancer using cisplatin-based concurrent chemoradiotherapy, substantial treatment failure still occurs, especially in advanced-stage patients and early-stage cervical cancer patients with high-risk prognostic factors.
Therefore, efforts to further improve the survival and quality of life of these patients are necessary.
Nedaplatin (cis-diammine-glycoplatinum), a derivative of cisplatin, was developed with the aim of producing a treatment with a similar effectiveness to cisplatin but decreased renal and gastrointestinal toxicities.
Based on the promising results of preclinical studies, the clinical efficacy of nedaplatin as a radiosensitizing agent was evaluated in patients with cervical cancer.
Retrospective analysis of nedaplatin-based concurrent chemoradiotherapy (CCRT) against cervical cancer suggested that nedaplatin-based CCRT can be considered as an alternative to cisplatin-based CCRT in both early-stage and advanced-stage cervical cancer patients.
However, due to the lack of a randomized controlled study, nedaplatin-based CCRT has not been convincingly proven to be clinically effective in patients with cervical cancer.
Further investigations in randomized controlled trials are therefore needed.
American Psychological Association (APA)
Mabuchi, Seiji& Kimura, Tadashi. 2010. Nedaplatin : A Radiosensitizing Agent for Patients with Cervical Cancer. Chemotherapy Research and Practice،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-511839
Modern Language Association (MLA)
Mabuchi, Seiji& Kimura, Tadashi. Nedaplatin : A Radiosensitizing Agent for Patients with Cervical Cancer. Chemotherapy Research and Practice No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-511839
American Medical Association (AMA)
Mabuchi, Seiji& Kimura, Tadashi. Nedaplatin : A Radiosensitizing Agent for Patients with Cervical Cancer. Chemotherapy Research and Practice. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-511839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511839