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Regulation of Senescence in Cancer and Aging
Joint Authors
Zhang, Hong
Cui, Hang
Ramkumar, Charusheila
Kong, Yahui
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-08
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress.
This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by contributing to aging.
The emergence of senescence as an effective tumor suppression mechanism is highlighted by recent demonstration that senescence prevents proliferation of cells at risk of neoplastic transformation.
Consequently, induction of senescence is recognized as a potential treatment of cancer.
Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells.
In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging.
The potential utility of senescence in cancer therapeutics will also be discussed.
American Psychological Association (APA)
Kong, Yahui& Cui, Hang& Ramkumar, Charusheila& Zhang, Hong. 2011. Regulation of Senescence in Cancer and Aging. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-511840
Modern Language Association (MLA)
Kong, Yahui…[et al.]. Regulation of Senescence in Cancer and Aging. Journal of Aging Research No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-511840
American Medical Association (AMA)
Kong, Yahui& Cui, Hang& Ramkumar, Charusheila& Zhang, Hong. Regulation of Senescence in Cancer and Aging. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-511840
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511840