Resveratrol : Why Is It a Promising Therapy for Chronic Kidney Disease Patients?
Joint Authors
Carraro-Eduardo, José Carlos
Leal, Viviane de O.
Mafra, Denise
Saldanha, Juliana F.
Stenvinkel, Peter
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Resveratrol, a phenolic compound found in various plants, including grapes, berries, and peanuts, shows promise for the treatment of cancer, aging, type 2 diabetes, and cardiovascular diseases.
Resveratrol can promote transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) activation, increase the expression level of SIRT-1, which is a sirtuin family protein, and reduce mTOR pathway signaling.
This compound has anti-inflammatory properties in that it inhibits or antagonizes the nuclear factor-κB (NF-κB) activity, which is a redox-sensitive transcription factor that coordinates the inflammatory response.
Inflammation and oxidative stress, which are common features in patients with chronic kidney disease (CKD), are interrelated and associated with cardiovascular disease and the progression of CKD itself.
Because of the modulation of the mechanisms involved in the inflammatory-oxidative stress cycle, resveratrol could play an important role in controlling CKD-related metabolic derangements.
Although resveratrol supplementation in theory is a promising therapy in this patient group, there are no studies evaluating its effects.
Thus, the present review aims to describe the role of resveratrol in inflammation and oxidative stress modulation and its possible benefits to patients with CKD.
American Psychological Association (APA)
Saldanha, Juliana F.& Leal, Viviane de O.& Stenvinkel, Peter& Carraro-Eduardo, José Carlos& Mafra, Denise. 2013. Resveratrol : Why Is It a Promising Therapy for Chronic Kidney Disease Patients?. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-511846
Modern Language Association (MLA)
Saldanha, Juliana F.…[et al.]. Resveratrol : Why Is It a Promising Therapy for Chronic Kidney Disease Patients?. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-511846
American Medical Association (AMA)
Saldanha, Juliana F.& Leal, Viviane de O.& Stenvinkel, Peter& Carraro-Eduardo, José Carlos& Mafra, Denise. Resveratrol : Why Is It a Promising Therapy for Chronic Kidney Disease Patients?. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-511846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511846