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Liquid Chromatographic Method for the Quantification of Antipsychotic Agent Iloperidone in Pharmaceutical Formulation
Joint Authors
Patel, Jigar R.
Chhalotiya, Usmangani K.
Shah, Dimal A.
Bhatt, Kashyap K.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Liquid chromatographic method for the quantitative determination of iloperidone in the pharmaceutical dosage form was developed.
A reversed phase column with mobile phase containing 0.02 M potassium dihydrogen phosphate: methanol: acetonitrile (55 : 25 : 20, v/v/v, pH 4 adjusted with phosphoric acid) was used.
The flow rate was 1.0 mL min−1, and effluents were monitored at 230 nm.
The retention time of iloperidone was 11.6 min.
Iloperidone stock solutions were subjected to acid and alkali hydrolysis, chemical oxidation, and dry heat degradation.
The degraded product peaks were well resolved from the pure drug peak with significant difference in their retention time values.
Stressed samples were assayed using developed LC method.
The proposed method was validated with respect to linearity, accuracy, precision, and robustness.
The method was successfully applied to the estimation of iloperidone in tablet dosage forms.
American Psychological Association (APA)
Chhalotiya, Usmangani K.& Bhatt, Kashyap K.& Shah, Dimal A.& Patel, Jigar R.. 2012. Liquid Chromatographic Method for the Quantification of Antipsychotic Agent Iloperidone in Pharmaceutical Formulation. ISRN Analytical Chemistry،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-511851
Modern Language Association (MLA)
Chhalotiya, Usmangani K.…[et al.]. Liquid Chromatographic Method for the Quantification of Antipsychotic Agent Iloperidone in Pharmaceutical Formulation. ISRN Analytical Chemistry No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-511851
American Medical Association (AMA)
Chhalotiya, Usmangani K.& Bhatt, Kashyap K.& Shah, Dimal A.& Patel, Jigar R.. Liquid Chromatographic Method for the Quantification of Antipsychotic Agent Iloperidone in Pharmaceutical Formulation. ISRN Analytical Chemistry. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-511851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511851