Postoperative Radiotherapy after Radical Prostatectomy : Indications and Open Questions
Joint Authors
Zwahlen, Daniel
Ghadjar, Pirus
Zimmermann, F.
Aebersold, Daniel M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Biochemical relapse after radical prostatectomy occurs in approximately 15–40% of patients within 5 years.
Postoperative radiotherapy is the only curative treatment for these patients.
After radical prostatectomy, two different strategies can be offered, adjuvant or salvage radiotherapy.
Adjuvant radiotherapy is defined as treatment given directly after surgery in the presence of risk factors (R1 resection, pT3) before biochemical relapse occurs.
It consists of 60–64 Gy and was shown to increase biochemical relapse-free survival in three randomized controlled trials and to increase overall survival after a median followup of 12.7 years in one of these trials.
Salvage radiotherapy, on the other hand, is given upon biochemical relapse and is the preferred option, by many centers as it does not include patients who might be cured by surgery alone.
As described in only retrospective studies the dose for salvage radiotherapy ranges from 64 to 72 Gy and is usually dependent on the absence or presence of macroscopic recurrence.
Randomized trials are currently investigating the role of adjuvant and salvage radiotherapy.
Patients with biochemical relapse after prostatectomy should at the earliest sign of relapse be referred to salvage radiotherapy and should preferably be treated within a clinical trial.
American Psychological Association (APA)
Ghadjar, Pirus& Zwahlen, Daniel& Aebersold, Daniel M.& Zimmermann, F.. 2012. Postoperative Radiotherapy after Radical Prostatectomy : Indications and Open Questions. Prostate Cancer،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-511856
Modern Language Association (MLA)
Ghadjar, Pirus…[et al.]. Postoperative Radiotherapy after Radical Prostatectomy : Indications and Open Questions. Prostate Cancer No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-511856
American Medical Association (AMA)
Ghadjar, Pirus& Zwahlen, Daniel& Aebersold, Daniel M.& Zimmermann, F.. Postoperative Radiotherapy after Radical Prostatectomy : Indications and Open Questions. Prostate Cancer. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-511856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511856