ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma
Joint Authors
Takano, Yasuo
Li, Xiaohan
Kikuchi, Keiji
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world.
The evolution and progression of HNSCC are considered to result from multiple stepwise alterations of cellular and molecular pathways in squamous epithelium.
Recently, inhibitor of growth gene (ING) family consisting of five genes, ING1 to ING5, was identified as a new tumor suppressor gene family that was implicated in the downregulation of cell cycle and chromatin remodeling.
In contrast, it has been shown that ING1 and ING2 play an oncogenic role in some cancers, this situation being similar to TGF-β.
In HNSCC, the ING family has been reported to be downregulated, and ING translocation from the nucleus to the cytoplasm may be a critical event for carcinogenesis.
In this paper, we describe our recent results and briefly summarize current knowledge regarding the biologic functions of ING in HNSCC.
American Psychological Association (APA)
Li, Xiaohan& Kikuchi, Keiji& Takano, Yasuo. 2010. ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma. Journal of Oncology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-511877
Modern Language Association (MLA)
Li, Xiaohan…[et al.]. ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma. Journal of Oncology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-511877
American Medical Association (AMA)
Li, Xiaohan& Kikuchi, Keiji& Takano, Yasuo. ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma. Journal of Oncology. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-511877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511877