Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population : A Minireview
Joint Authors
Chua, Kek Heng
Phipps, Maude Elvira
Chai, Hwa Chia
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
SLE is an autoimmune disease that is not uncommon in Malaysia.
In contrast to Malays and Indians, the Chinese seem to be most affected.
SLE is characterized by deficiency of body's immune response that leads to production of autoantibodies and failure of immune complex clearance.
This minireview attempts to summarize the association of several candidate genes with risk for SLE in the Malaysian population and discuss the genetic heterogeneity that exists locally in Asians and in comparison with SLE in Caucasians.
Several groups of researchers have been actively investigating genes that are associated with SLE susceptibility in the Malaysian population by screening possible reported candidate genes across the SLE patients and healthy controls.
These candidate genes include MHC genes and genes encoding complement components, TNF, FcγR, T-cell receptors, and interleukins.
However, most of the polymorphisms investigated in these genes did not show significant associations with susceptibility to SLE in the Malaysian scenario, except for those occurring in MHC genes and genes coding for TNF-α, IL-1β, IL-1RN, and IL-6.
American Psychological Association (APA)
Chai, Hwa Chia& Phipps, Maude Elvira& Chua, Kek Heng. 2011. Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population : A Minireview. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511887
Modern Language Association (MLA)
Chai, Hwa Chia…[et al.]. Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population : A Minireview. Clinical and Developmental Immunology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-511887
American Medical Association (AMA)
Chai, Hwa Chia& Phipps, Maude Elvira& Chua, Kek Heng. Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population : A Minireview. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511887