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Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Multiple sclerosis (MS) is an inflammatory disease in which the myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms.
It is caused by an autoimmune response to self-antigens in a genetically susceptible individual induced by unknown environmental factors.
Principal cells of the immune system that drive the immunopathological processes are T cells, especially of TH1 and TH17 subsets.
However, in recent years, it was disclosed that regulatory T cells took part in, too.
Subsequently, there was endeavour to develop ways how to re-establish their physiological functions.
In this review, we describe known mechanisms of action, efficacy, and side-effects of contemporary and emerging MS immunotherapeutical agents on Treg cells and other cells of the immune system involved in the immunopathogenesis of the disease.
Furthermore, we discuss how laboratory immunology can offer physicians its help in the diagnosis process and decisions what kind of biological therapy should be used.
American Psychological Association (APA)
Buc, Milan. 2013. Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-511889
Modern Language Association (MLA)
Buc, Milan. Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-511889
American Medical Association (AMA)
Buc, Milan. Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-511889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511889