The Role of Tetrahydrobiopterin and Dihydrobiopterin in IschemiaReperfusion Injury When Given at Reperfusion
Joint Authors
Perkins, Kerry-Anne
Young, Lindon H.
Zambrano, Christopher
Pershad, Sailesh
Adams, Jovan S.
McGraw, Sloane
Emrich, Jeffrey
Chen, Qian
Krass, Samuel
Kay, Helen
Elio, Katrina
Teng, Jane Chun-wen
Kim, Elizabeth Eun Jung
Source
Advances in Pharmacological Sciences
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Reduced nitric oxide (NO) bioavailability and increased oxidative stress are major factors mediating ischemia/reperfusion (I/R) injury.
Tetrahydrobiopterin (BH4) is an essential cofactor of endothelial NO synthase (eNOS) to produce NO, whereas dihydrobiopterin (BH2) can shift the eNOS product profile from NO to superoxide, which is further converted to hydrogen peroxide (H2O2) and cause I/R injury.
The effects of BH4 and BH2 on oxidative stress and postreperfused cardiac functions were examined in ex vivo myocardial and in vivo femoral I (20 min)/R (45 min) models.
In femoral I/R, BH4 increased NO and decreased H2O2 releases relative to saline control, and these effects correlated with improved postreperfused cardiac function.
By contrast, BH2 decreased NO release relative to the saline control, but increased H2O2 release similar to the saline control, and these effects correlated with compromised postreperfused cardiac function.
In conclusion, these results suggest that promoting eNOS coupling to produce NO and decrease H2O2 may be a key mechanism to restore postreperfused organ function during early reperfusion.
American Psychological Association (APA)
Chen, Qian& Kim, Elizabeth Eun Jung& Elio, Katrina& Zambrano, Christopher& Krass, Samuel& Teng, Jane Chun-wen…[et al.]. 2010. The Role of Tetrahydrobiopterin and Dihydrobiopterin in IschemiaReperfusion Injury When Given at Reperfusion. Advances in Pharmacological Sciences،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-511900
Modern Language Association (MLA)
Chen, Qian…[et al.]. The Role of Tetrahydrobiopterin and Dihydrobiopterin in IschemiaReperfusion Injury When Given at Reperfusion. Advances in Pharmacological Sciences No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-511900
American Medical Association (AMA)
Chen, Qian& Kim, Elizabeth Eun Jung& Elio, Katrina& Zambrano, Christopher& Krass, Samuel& Teng, Jane Chun-wen…[et al.]. The Role of Tetrahydrobiopterin and Dihydrobiopterin in IschemiaReperfusion Injury When Given at Reperfusion. Advances in Pharmacological Sciences. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-511900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511900