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The Immunocytochemistry Is a Valuable Tool in the Diagnosis of Papillary Thyroid Cancer in FNA's Using Liquid-Based Cytology
Joint Authors
Mygdakos, Nikolas
Boglou, Kyriaki
kiziridou, Anastasia
Pazaitou-Panayiotou, Kalliopi
Chrisoulidou, Alexandra
Destouni, Chariklia
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid.
An accurate cytological diagnosis is based on distinctive cytological features in combination with immunocytochemistry.
Methods.
A number of 83 fine needle aspirations, positive for papillary thyroid cancer (44 from thyroid nodules and 39 from cervical lymph nodes), were studied using Thin Layer Cytology.
A panel of the immunomarkers Cytokeratin-19, Galectin-3, HBME1, CD-44, CD-56, and E-Cadherin was performed.
Results.
Positive expression of CK-19 was observed in 77 cases (92.7%), of Galectin-3 in 74 cases (89.1%), of HBME1 in 65 (78.3%), and of CD-44 in 72 cases (86.7%).
Loss of expression of CD-56 was observed in 80 cases (96.4%) and of E-cadherin in 78 (93.9%).
Conclusions.
Our data suggest that Thin Layer Cytology increases the diagnostic accuracy in papillary carcinoma and seems to be a promising technique for further investigation of thyroid lesions permitting the possibility to use archive material.
Positive immunoexpression of CK-19, Galectin-3, HBME-1, and CD-44 improves the diagnostic accuracy of papillary thyroid cancer.
Furthermore, loss of E-cadherin and of CD-56 expression is a feature of malignancy.
American Psychological Association (APA)
Pazaitou-Panayiotou, Kalliopi& Mygdakos, Nikolas& Boglou, Kyriaki& kiziridou, Anastasia& Chrisoulidou, Alexandra& Destouni, Chariklia. 2010. The Immunocytochemistry Is a Valuable Tool in the Diagnosis of Papillary Thyroid Cancer in FNA's Using Liquid-Based Cytology. Journal of Oncology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-511902
Modern Language Association (MLA)
Pazaitou-Panayiotou, Kalliopi…[et al.]. The Immunocytochemistry Is a Valuable Tool in the Diagnosis of Papillary Thyroid Cancer in FNA's Using Liquid-Based Cytology. Journal of Oncology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-511902
American Medical Association (AMA)
Pazaitou-Panayiotou, Kalliopi& Mygdakos, Nikolas& Boglou, Kyriaki& kiziridou, Anastasia& Chrisoulidou, Alexandra& Destouni, Chariklia. The Immunocytochemistry Is a Valuable Tool in the Diagnosis of Papillary Thyroid Cancer in FNA's Using Liquid-Based Cytology. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-511902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511902