Stem Cell Transplantation for Muscular Dystrophy : The Challenge of Immune Response
Joint Authors
English, Karen
Noviello, Maddalena
Tedesco, Francesco Saverio
Maffioletti, Sara Martina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Treating muscle disorders poses several challenges to the rapidly evolving field of regenerative medicine.
Considerable progress has been made in isolating, characterizing, and expanding myogenic stem cells and, although we are now envisaging strategies to generate very large numbers of transplantable cells (e.g., by differentiating induced pluripotent stem cells), limitations directly linked to the interaction between transplanted cells and the host will continue to hamper a successful outcome.
Among these limitations, host inflammatory and immune responses challenge the critical phases after cell delivery, including engraftment, migration, and differentiation.
Therefore, it is key to study the mechanisms and dynamics that impair the efficacy of cell transplants in order to develop strategies that can ultimately improve the outcome of allogeneic and autologous stem cell therapies, in particular for severe disease such as muscular dystrophies.
In this review we provide an overview of the main players and issues involved in this process and discuss potential approaches that might be beneficial for future regenerative therapies of skeletal muscle.
American Psychological Association (APA)
Maffioletti, Sara Martina& Noviello, Maddalena& English, Karen& Tedesco, Francesco Saverio. 2014. Stem Cell Transplantation for Muscular Dystrophy : The Challenge of Immune Response. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-511912
Modern Language Association (MLA)
Maffioletti, Sara Martina…[et al.]. Stem Cell Transplantation for Muscular Dystrophy : The Challenge of Immune Response. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-511912
American Medical Association (AMA)
Maffioletti, Sara Martina& Noviello, Maddalena& English, Karen& Tedesco, Francesco Saverio. Stem Cell Transplantation for Muscular Dystrophy : The Challenge of Immune Response. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-511912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511912