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Cladribine and Fludarabine Nucleoside Change the Levels of CD Antigens on B-Lymphoproliferative Disorders
Joint Authors
Christopherson, Richard I.
Cassano, Carlos
Huang, Pauline
Mulligan, Stephen P.
Mactier, Swetlana
Belov, Larissa
Source
International Journal of Proteomics
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The purine analogs, fludarabine nucleoside (FdA), and cladribine (CdA) (1 μM, 24 hours), significantly changed the levels of some surface antigens on the human B-cell lines MEC2 and Raji.
Changes in the surface proteins were identified using a Cluster of Differentiation (CD) antibody microarray that captures live cells and confirmed by flow cytometry.
For Raji cells, CdA up-regulated CD10, CD54, CD80, and CD86, with repression of CD22, while FdA up-regulated CD20, CD54, CD80, CD86 and CD95.
For MEC2 cells, CdA up-regulated CD11a, CD20, CD43, CD45, CD52, CD54, CD62L, CD80, CD86, and CD95, but FdA had no effect.
Up-regulation of particular CD antigens induced on a B-cell lymphoproliferative disorder by a purine analog could provide targets for therapeutic antibodies with synergistic cell killing.
American Psychological Association (APA)
Cassano, Carlos& Mactier, Swetlana& Mulligan, Stephen P.& Belov, Larissa& Huang, Pauline& Christopherson, Richard I.. 2010. Cladribine and Fludarabine Nucleoside Change the Levels of CD Antigens on B-Lymphoproliferative Disorders. International Journal of Proteomics،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-511938
Modern Language Association (MLA)
Cassano, Carlos…[et al.]. Cladribine and Fludarabine Nucleoside Change the Levels of CD Antigens on B-Lymphoproliferative Disorders. International Journal of Proteomics No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-511938
American Medical Association (AMA)
Cassano, Carlos& Mactier, Swetlana& Mulligan, Stephen P.& Belov, Larissa& Huang, Pauline& Christopherson, Richard I.. Cladribine and Fludarabine Nucleoside Change the Levels of CD Antigens on B-Lymphoproliferative Disorders. International Journal of Proteomics. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-511938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511938