Harnessing the Helminth Secretome for Therapeutic Immunomodulators
Joint Authors
Ditgen, Dana
Brattig, Norbert
Meissner, Kamila A.
Liebau, Eva
Anandarajah, Emmanuela M.
Wrenger, Carsten
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Helminths are the largest and most complex pathogens to invade and live within the human body.
Since they are not able to outpace the immune system by rapid antigen variation or faster cell division or retreat into protective niches not accessible to immune effector mechanisms, their long-term survival depends on influencing and regulating the immune responses away from the mode of action most damaging to them.
Immunologists have focused on the excretory and secretory products that are released by the helminths, since they can change the host environment by modulating the immune system.
Here we give a brief overview of the helminth-associated immune response and the currently available helminth secretome data.
We introduce some major secretome-derived immunomodulatory molecules and describe their potential mode of action.
Finally, the applicability of helminth-derived therapeutic proteins in the treatment of allergic and autoimmune inflammatory disease is discussed.
American Psychological Association (APA)
Ditgen, Dana& Anandarajah, Emmanuela M.& Meissner, Kamila A.& Brattig, Norbert& Wrenger, Carsten& Liebau, Eva. 2014. Harnessing the Helminth Secretome for Therapeutic Immunomodulators. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-511947
Modern Language Association (MLA)
Ditgen, Dana…[et al.]. Harnessing the Helminth Secretome for Therapeutic Immunomodulators. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-511947
American Medical Association (AMA)
Ditgen, Dana& Anandarajah, Emmanuela M.& Meissner, Kamila A.& Brattig, Norbert& Wrenger, Carsten& Liebau, Eva. Harnessing the Helminth Secretome for Therapeutic Immunomodulators. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-511947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511947