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Astroglial Integrins in the Development and Regulation of Neurovascular Units
Joint Authors
Okamoto, Takayuki
Tanigami, Hironobu
Shimaoka, Motomu
Yasue, Yuichi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In the neurovascular units of the central nervous system, astrocytes form extensive networks that physically and functionally connect the neuronal synapses and the cerebral vascular vessels.
This astrocytic network is thought to be critically important for coupling neuronal signaling activity and energy demand with cerebral vascular tone and blood flow.
To establish and maintain this elaborate network, astrocytes must precisely calibrate their perisynaptic and perivascular processes in order to sense and regulate neuronal and vascular activities, respectively.
Integrins, a prominent family of cell-adhesion molecules that support astrocytic migration in the brain during developmental and normal adult stages, have been implicated in regulating the integrity of the blood brain barrier and the tripartite synapse to facilitate the formation of a functionally integrated neurovascular unit.
This paper describes the significant roles that integrins and connexins play not only in regulating astrocyte migration during the developmental and adult stages of the neurovascular unit, but also in general health and in such diseases as hepatic encephalopathy.
American Psychological Association (APA)
Tanigami, Hironobu& Okamoto, Takayuki& Yasue, Yuichi& Shimaoka, Motomu. 2012. Astroglial Integrins in the Development and Regulation of Neurovascular Units. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-511968
Modern Language Association (MLA)
Tanigami, Hironobu…[et al.]. Astroglial Integrins in the Development and Regulation of Neurovascular Units. Pain Research and Treatment No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-511968
American Medical Association (AMA)
Tanigami, Hironobu& Okamoto, Takayuki& Yasue, Yuichi& Shimaoka, Motomu. Astroglial Integrins in the Development and Regulation of Neurovascular Units. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-511968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511968