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Regulation of CDK9 Activity by Phosphorylation and Dephosphorylation
Joint Authors
Breuer, Denitra
Petukhov, Michael
Nekhai, Sergei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
HIV-1 transcription is regulated by CDK9/cyclin T1, which, unlike a typical cell cycle-dependent kinase, is regulated by associating with 7SK small nuclear ribonuclear protein complex (snRNP).
While the protein components of this complex are well studied, the mechanism of the complex formation is still not fully understood.
The association of CDK9/cyclin T1 with 7SK snRNP is, in part, regulated by a reversible CDK9 phosphorylation.
Here, we present a comprehensive review of the kinases and phosphatases involved in CDK9 phosphorylation and discuss their role in regulation of HIV-1 replication and potential for being targeted for drug development.
We propose a novel pathway of HIV-1 transcription regulation via CDK9 Ser-90 phosphorylation by CDK2 and CDK9 Ser-175 dephosphorylation by protein phosphatase-1.
American Psychological Association (APA)
Nekhai, Sergei& Petukhov, Michael& Breuer, Denitra. 2014. Regulation of CDK9 Activity by Phosphorylation and Dephosphorylation. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-511996
Modern Language Association (MLA)
Nekhai, Sergei…[et al.]. Regulation of CDK9 Activity by Phosphorylation and Dephosphorylation. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-511996
American Medical Association (AMA)
Nekhai, Sergei& Petukhov, Michael& Breuer, Denitra. Regulation of CDK9 Activity by Phosphorylation and Dephosphorylation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-511996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511996