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Plasma Volume Expansion Resulting from Intravenous Glucose Tolerance Test
Joint Authors
Nyström, Thomas
Hahn, Robert G.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
To quantify the degree of plasma volume expansion that occurs during an intravenous glucose tolerance test (IVGTT).
Methods.
Twenty healthy volunteers (mean age, 28 years) underwent IVGTTs in which 0.3 g/kg of glucose 30% was injected as a bolus over 1 min.
Twelve blood samples were collected over 75 min.
The plasma glucose and blood hemoglobin concentrations were used to calculate the volume distribution (Vd) and the clearance (CL) of both the exogenous glucose and the injected fluid volume.
Results.
The IVGTT caused a virtually instant plasma volume expansion of 10%.
The half-life of the glucose averaged 15 min and the plasma volume expansion 16 min.
Correction of the fluid kinetic model for osmotic effects after injection reduced CL for the infused volume by 85%, which illustrates the strength of osmosis in allocating fluid back to the intracellular fluid space.
Simulations indicated that plasma volume expansion can be reduced to 60% by increasing the injection time from 1 to 5 min and reducing the glucose load from 0.3 to 0.2 g/kg.
Conclusion.
A regular IVGTT induced an acute plasma volume expansion that peaked at 10% despite the fact that only 50–80 mL of fluid were administered.
American Psychological Association (APA)
Hahn, Robert G.& Nyström, Thomas. 2011. Plasma Volume Expansion Resulting from Intravenous Glucose Tolerance Test. Computational and Mathematical Methods in Medicine،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-512005
Modern Language Association (MLA)
Hahn, Robert G.& Nyström, Thomas. Plasma Volume Expansion Resulting from Intravenous Glucose Tolerance Test. Computational and Mathematical Methods in Medicine No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-512005
American Medical Association (AMA)
Hahn, Robert G.& Nyström, Thomas. Plasma Volume Expansion Resulting from Intravenous Glucose Tolerance Test. Computational and Mathematical Methods in Medicine. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-512005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512005