Salusins : Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases
Joint Authors
Sato, Kengo
Shichiri, Masayoshi
Watanabe, Rena
Itoh, Fumiko
Watanabe, Takuya
Source
International Journal of Hypertension
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Human salusin-α and salusin-β are related peptides produced from prosalusin.
Bolus injection of salusin-β into rats induces more profound hypotension and bradycardia than salusin-α.
Central administration of salusin-β increases blood pressure via release of norepinephrine and arginine-vasopressin.
Circulating levels of salusin-α and salusin-β are lower in patients with essential hypertension.
Salusin-β exerts more potent mitogenic effects on human vascular smooth muscle cells (VSMCs) and fibroblasts than salusin-α.
Salusin-β accelerates inflammatory responses in human endothelial cells and monocyte-endothelial adhesion.
Human macrophage foam cell formation is stimulated by salusin-β but suppressed by salusin-α.
Chronic salusin-β infusion into apolipoprotein E-deficient mice enhances atherosclerotic lesions; salusin-α infusion reduces lesions.
Salusin-β is expressed in proliferative neointimal lesions of porcine coronary arteries after stenting.
Salusin-α and salusin-β immunoreactivity have been detected in human coronary atherosclerotic plaques, with dominance of salusin-β in macrophage foam cells, VSMCs, and fibroblasts.
Circulating salusin-β levels increase and salusin-α levels decrease in patients with coronary artery disease.
These findings suggest that salusin-β and salusin-α may contribute to proatherogenesis and antiatherogenesis, respectively.
Increased salusin-β and/or decreased salusin-α levels in circulating blood and vascular tissue are closely linked with atherosclerosis.
Salusin-α and salusin-β could be candidate biomarkers and therapeutic targets for atherosclerotic cardiovascular diseases.
American Psychological Association (APA)
Sato, Kengo& Watanabe, Rena& Itoh, Fumiko& Shichiri, Masayoshi& Watanabe, Takuya. 2013. Salusins : Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512012
Modern Language Association (MLA)
Sato, Kengo…[et al.]. Salusins : Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases. International Journal of Hypertension No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-512012
American Medical Association (AMA)
Sato, Kengo& Watanabe, Rena& Itoh, Fumiko& Shichiri, Masayoshi& Watanabe, Takuya. Salusins : Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512012