Effect of Chemical Enhancers in Transdermal Permeation of Alfuzosin Hydrochloride
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The objective of the present study is to explore the efficient chemical penetration enhancer among the various enhancers available in overcoming the stratum corneum barrier in transdermal delivery of Alfuzosin hydrochloride (AH).
The different enhancers were incorporated in 2% Carbopol gel which was selected as a control and evaluated by in vitro diffusion studies through dialysis membrane and permeation through the rat abdominal skin using Keshary-Chien diffusion cells.
All the enhancers increased the release rate through the dialysis membrane when compared with control except oleic acid which decreased the release rate but showed maximum solubility of the drug.
Among the various enhancers Transcutol 20% and tween-20 (2%) showed the highest cumulative amount (Q24) of 702.28 ± 6.97 μg/cm2 and 702.74 ± 7.49 μg/cm2, respectively.
A flux rate of 31.08 ± 0.21 μg/cm2/hr by Transcutol 20% and 30.38 ± 0.18 μg/cm2/hr by tween-20 (2%) was obtained.
Transcutol 20% showed decreased lag time of 0.13 ± 0.05 hr.
The lowest skin content of 342.33 ± 5.30 μg/gm was seen with oleic acid 2.5%.
Maximum enhancement of flux by 3.94-fold was obtained with transcutol 20%.
Primary skin irritation studies were performed with rabbit.
Histopathological studies of transcutol 20% showed marked changes such as degeneration and infiltration of mononuclear cells in dermis indicating the effect of transcutol on the skin.
Among the different enhancers transcutol is efficient in enhancing transdermal delivery of AH.
American Psychological Association (APA)
Prasanthi, D.& Lakshmi, P. K.. 2012. Effect of Chemical Enhancers in Transdermal Permeation of Alfuzosin Hydrochloride. ISRN Pharmaceutics،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-512028
Modern Language Association (MLA)
Prasanthi, D.& Lakshmi, P. K.. Effect of Chemical Enhancers in Transdermal Permeation of Alfuzosin Hydrochloride. ISRN Pharmaceutics No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-512028
American Medical Association (AMA)
Prasanthi, D.& Lakshmi, P. K.. Effect of Chemical Enhancers in Transdermal Permeation of Alfuzosin Hydrochloride. ISRN Pharmaceutics. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-512028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512028