Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase- (MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells
Joint Authors
Lu, Jiahui
Xie, Jing
Wang, Zhenzuo
Liu, Yan
Wang, Di
Meng, Qingfan
Teng, Lesheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Liquiritigenin (LQ), separated from Glycyrrhiza radix, possesses anti-inflammatory, antihyperlipidemic, and antiallergic effects.
Our present study aims to investigate the antihepatocellular carcinoma effects of LQ both in cell and animal models.
LQ strikingly reduced cell viability, enhanced apoptotic rate, induced lactate dehydrogenase over-release, and increased intracellular reactive oxygen species (ROS) level and caspase 3 activity in both PLC/PRL/5 and HepG2 cells.
The expression of cleaved PARP, the hall-marker of apoptosis, was enhanced by LQ.
LQ treatment resulted in a reduction of the expressions of B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma-extra large (Bcl-xL), and an increase of the phosphorylation of c-Jun N-terminal kinases (JNK) and P38.
LQ-mediated cell viability reduction, mitochondrial dysfunction, apoptosis related protein abnormal expressions, and JNK and P38 activation were partially abolished by N-Acetyl-L-cysteine (a ROS inhibitor) pretreatment.
Moreover, LQ suppressed the activation of extracellular signaling-regulated kinase (ERKs) and reduced the translocation of phosphor-ERKs from cytoplasm to nucleus.
This antitumor activity was further confirmed in PLC/PRL/5-xenografted mice model.
All these data indicate that the antihepatocellular carcinoma effects of LQ are related to its modulation of the activations of mitogen-activated protein kinase (MAPKs).
The study provides experimental evidence supporting LQ as a potential therapeutic agent for hepatocellular carcinoma treatment.
American Psychological Association (APA)
Wang, Di& Lu, Jiahui& Liu, Yan& Meng, Qingfan& Xie, Jing& Wang, Zhenzuo…[et al.]. 2014. Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase- (MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-512034
Modern Language Association (MLA)
Wang, Di…[et al.]. Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase- (MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-512034
American Medical Association (AMA)
Wang, Di& Lu, Jiahui& Liu, Yan& Meng, Qingfan& Xie, Jing& Wang, Zhenzuo…[et al.]. Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase- (MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-512034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512034