![](/images/graphics-bg.png)
Hemoglobin A1C Percentage in Nonhuman Primates : A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation
Joint Authors
Bottino, Rita
Bertera, Suzanne
Marigliano, Marco
Casu, Anna
Trucco, Massimo
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Non-human primates (NHPs) are a very valuable experimental model for diabetes research studies including experimental pancreatic islet transplantation.
In particular NHPs are the recipients of choice to validate pigs as possible source of pancreatic islets.
The aim of this study was to quantify glycated hemoglobin percentage in NHPs and to assess whether changes in values reflect the metabolic trends after diabetes induction and islet transplantation.
Sera from 15 NHPs were analyzed.
9 NHPs were rendered diabetic with streptozotocin (STZ), and 3 of them received porcine islet transplants.
Hemoglobin A1c (HbA1c) percentage was measured with an assay based on a latex immunoagglutination inhibition methodology.
Whereas diabetes and its duration were associated with increasing HbA1c levels, postislet transplantation blood glucose normalization was paralleled by a decrease in the HbA1c percentage.
Our data provide evidence that HbA1c is a useful tool to monitor glucose metabolism in NHPs.
American Psychological Association (APA)
Marigliano, Marco& Casu, Anna& Bertera, Suzanne& Trucco, Massimo& Bottino, Rita. 2011. Hemoglobin A1C Percentage in Nonhuman Primates : A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-512057
Modern Language Association (MLA)
Marigliano, Marco…[et al.]. Hemoglobin A1C Percentage in Nonhuman Primates : A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation. Journal of Transplantation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-512057
American Medical Association (AMA)
Marigliano, Marco& Casu, Anna& Bertera, Suzanne& Trucco, Massimo& Bottino, Rita. Hemoglobin A1C Percentage in Nonhuman Primates : A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-512057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512057