Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters
Joint Authors
González-Chávez, A.
Suárez-Álvarez, K.
Escobedo, Galileo
De León-Nava, M. A.
Hernández-Ruiz, J.
Serralde-Zúñiga, A. E.
Galindo-González, F. J.
Robles-Díaz, G.
Zavala-Castillo, J. C.
Quiñones-Álvarez, M. S.
Leon-Cabrera, Sonia
Ramírez-Velásquez, J.
Gómez-Hernández, G.
Solís-Lozano, L.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Interleukin-(IL-) 12 has been recently suggested to participate during development of insulin resistance in obese mice.
Nevertheless, serum IL-12 levels have not been accurately determined in overweight and obese humans.
We thus studied serum concentrations of IL-12 in Mexican adult individuals, examining their relationship with low-grade inflammation and obesity-related parameters.
A total of 147 healthy individuals, 43 normal weight, 61 overweight, and 43 obese subjects participated in the study.
Circulating levels of IL-12, tumor necrosis factor-alpha (TNF-α), leptin, insulin, glucose, total cholesterol, and triglyceride were measured after overnight fasting in all of the study subjects.
Waist circumference and body fat percentage were recorded for all the participants.
Serum IL-12 was significantly higher in overweight and obese individuals than in normal weight controls.
Besides being strongly related with body mass index (r=0.5154), serum IL-12 exhibited a significant relationship with abdominal obesity (r=0.4481), body fat percentage (r=0.5625), serum glucose (r=0.3158), triglyceride (r=0.3714), and TNF-α (r=0.4717).
Thus, serum levels of IL-12 are increased in overweight and obese individuals and show a strong relationship with markers of low-grade inflammation and obesity in the Mexican adult population.
Further research is needed to understand the role of IL-12 in developing obesity-associated alterations in humans.
American Psychological Association (APA)
Suárez-Álvarez, K.& Solís-Lozano, L.& Leon-Cabrera, Sonia& González-Chávez, A.& Gómez-Hernández, G.& Quiñones-Álvarez, M. S.…[et al.]. 2013. Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512098
Modern Language Association (MLA)
Suárez-Álvarez, K.…[et al.]. Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-512098
American Medical Association (AMA)
Suárez-Álvarez, K.& Solís-Lozano, L.& Leon-Cabrera, Sonia& González-Chávez, A.& Gómez-Hernández, G.& Quiñones-Álvarez, M. S.…[et al.]. Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512098
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512098