Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions
Joint Authors
Fujii, Masayuki
Nakano, Shu-ichi
Sugimoto, Naoki
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Unnatural nucleosides have been explored to expand the properties and the applications of oligonucleotides.
This paper briefly summarizes nucleic acid analogs in which the base is modified or replaced by an unnatural stacking group for the study of nucleic acid interactions.
We also describe the nucleoside analogs of a base pair-mimic structure that we have examined.
Although the base pair-mimic nucleosides possess a simplified stacking moiety of a phenyl or naphthyl group, they can be used as a structural analog of Watson-Crick base pairs.
Remarkably, they can adopt two different conformations responding to their interaction energies, and one of them is the stacking conformation of the nonpolar aromatic group causing the site-selective flipping of the opposite base in a DNA double helix.
The base pair-mimic nucleosides can be used to study the mechanism responsible for the base stacking and the flipping of bases out of a nucleic acid duplex.
American Psychological Association (APA)
Nakano, Shu-ichi& Fujii, Masayuki& Sugimoto, Naoki. 2011. Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions. Journal of Nucleic Acids،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-512101
Modern Language Association (MLA)
Nakano, Shu-ichi…[et al.]. Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions. Journal of Nucleic Acids No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-512101
American Medical Association (AMA)
Nakano, Shu-ichi& Fujii, Masayuki& Sugimoto, Naoki. Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions. Journal of Nucleic Acids. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-512101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512101