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JC Polyomavirus (JCV) and Monoclonal Antibodies : Friends or Potential Foes?
Joint Authors
Diotti, Roberta Antonia
Clementi, Massimo
Mancini, Nicasio
Clementi, Nicola
Criscuolo, Elena
Solforosi, Laura
Nakanishi, Akira
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS), observed in immunodeficient patients and caused by JC virus ((JCV), also called JC polyomavirus (JCPyV)).
After the HIV pandemic and the introduction of immunomodulatory therapy, the PML incidence significantly increased.
The correlation between the use of natalizumab, a drug used in multiple sclerosis (MS), and the PML development of particular relevance.
The high incidence of PML in natalizumab-treated patients has highlighted the importance of two factors: the need of PML risk stratification among natalizumab-treated patients and the need of effective therapeutic options.
In this review, we discuss these two needs under the light of the major viral models of PML etiopathogenesis.
American Psychological Association (APA)
Diotti, Roberta Antonia& Nakanishi, Akira& Clementi, Nicola& Mancini, Nicasio& Criscuolo, Elena& Solforosi, Laura…[et al.]. 2013. JC Polyomavirus (JCV) and Monoclonal Antibodies : Friends or Potential Foes?. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-512142
Modern Language Association (MLA)
Diotti, Roberta Antonia…[et al.]. JC Polyomavirus (JCV) and Monoclonal Antibodies : Friends or Potential Foes?. Clinical and Developmental Immunology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-512142
American Medical Association (AMA)
Diotti, Roberta Antonia& Nakanishi, Akira& Clementi, Nicola& Mancini, Nicasio& Criscuolo, Elena& Solforosi, Laura…[et al.]. JC Polyomavirus (JCV) and Monoclonal Antibodies : Friends or Potential Foes?. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-512142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512142