Pathophysiology of Cisplatin-Induced Acute Kidney Injury
Joint Authors
Edelstein, Charles L.
Ozkok, Abdullah
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-06
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors.
A known complication of cisplatin administration is acute kidney injury (AKI).
The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal.
Recurrent episodes of AKI may result in chronic kidney disease.
The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, oxidative stress, inflammation, and vascular injury in the kidney.
There is predominantly acute tubular necrosis and also apoptosis in the proximal tubules.
There is activation of multiple proinflammatory cytokines and infiltration of inflammatory cells in the kidney.
Inhibition of the proinflammatory cytokines TNF-α or IL-33 or depletion of CD4+ T cells or mast cells protects against cisplatin-induced AKI.
Cisplatin also causes endothelial cell injury.
An understanding of the pathogenesis of cisplatin-induced AKI is important for the development of adjunctive therapies to prevent AKI, to lessen the need for dose decrease or drug withdrawal, and to lessen patient morbidity and mortality.
American Psychological Association (APA)
Ozkok, Abdullah& Edelstein, Charles L.. 2014. Pathophysiology of Cisplatin-Induced Acute Kidney Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-512149
Modern Language Association (MLA)
Ozkok, Abdullah& Edelstein, Charles L.. Pathophysiology of Cisplatin-Induced Acute Kidney Injury. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-512149
American Medical Association (AMA)
Ozkok, Abdullah& Edelstein, Charles L.. Pathophysiology of Cisplatin-Induced Acute Kidney Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-512149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512149