Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease
Joint Authors
Diaz, Natalie
Bronstein, Jeff
Vickrey, Barbara G.
Vassar, Stefanie D.
Hays, Ron D.
Bordelon, Yvette M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We assessed degree of Parkinson disease motor symptom improvement with medication among subjects enrolled in an ongoing, population-based study in Central California.
The motor section of the unified Parkinson disease rating scale (UPDRS) was performed on subjects in both OFF and ON medication states, and difference between these scores was used as an indicator of symptomatic benefit.
Higher OFF minus ON scores correlated with more severe baseline symptoms.
There was equivalent improvement on the motor UPDRS scale for subjects divided according to medication classes used: levodopa alone 7.3 points, levodopa plus other medications 8.5 points, and dopamine agonists but not levodopa 6.1 points.
In addition, there was no difference in the magnitude of improvement when subjects were divided according to Parkinson disease subtype, defined as tremor dominant, akinetic-rigid, or mixed.
In this community-based sample, these values are within the range of a clinically important difference as defined by previous studies.
American Psychological Association (APA)
Bordelon, Yvette M.& Hays, Ron D.& Vassar, Stefanie D.& Diaz, Natalie& Bronstein, Jeff& Vickrey, Barbara G.. 2011. Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease. BioMed Research International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-512150
Modern Language Association (MLA)
Bordelon, Yvette M.…[et al.]. Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease. BioMed Research International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-512150
American Medical Association (AMA)
Bordelon, Yvette M.& Hays, Ron D.& Vassar, Stefanie D.& Diaz, Natalie& Bronstein, Jeff& Vickrey, Barbara G.. Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-512150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512150