CUZD1 and Anti-CUZD1 Antibodies as Markers of Cancer and Inflammatory Bowel Diseases
Joint Authors
Papandreou, Christos N.
Bogdanos, Dimitrios P.
Liaskos, Christos
Orfanidou, Timoklia
Rigopoulou, Eirini I.
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
CUZD1, the CUB, and zona pellucida-like domains-containing protein 1, is a newly identified antigen of pancreatic autoantibodies (PAB) giving a reticulogranular pattern in patients with inflammatory bowel diseases, and in particular Crohn’s disease.
The exact mechanisms by which this pancreatic antigen becomes the target of IBD-specific pancreatic autoantibodies are unclear.
At the same time, evolving data strongly support a role for CUZD1 in carcinogenesis.
Human CUZD1 is mapped at chromosome 10q26.13 and the loss of this region is a frequent event in various malignant tumours.
mRNA overexpression of CUZD1 has been noted in ovarian cancer and serum levels of CUZD1 are elevated in women with ovarian cancer and patients suffering from pancreatic cancer.
CUZD1 appears to be one of the relatively few biomarkers that serve as both cancer biomarker and autoantigen of autoantibodies in an autoimmune disease unrelated to cancerous organs.
This review discusses the role of CUZD1 in cancer and autoimmunity.
We anticipate that a better understanding of the function of CUZD1 will help us to understand how it becomes the focus of an autoimmune attack specifically targeting the intestine and its enigmatic role in carcinogenesis.
American Psychological Association (APA)
Liaskos, Christos& Rigopoulou, Eirini I.& Orfanidou, Timoklia& Bogdanos, Dimitrios P.& Papandreou, Christos N.. 2013. CUZD1 and Anti-CUZD1 Antibodies as Markers of Cancer and Inflammatory Bowel Diseases. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-512173
Modern Language Association (MLA)
Liaskos, Christos…[et al.]. CUZD1 and Anti-CUZD1 Antibodies as Markers of Cancer and Inflammatory Bowel Diseases. Clinical and Developmental Immunology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-512173
American Medical Association (AMA)
Liaskos, Christos& Rigopoulou, Eirini I.& Orfanidou, Timoklia& Bogdanos, Dimitrios P.& Papandreou, Christos N.. CUZD1 and Anti-CUZD1 Antibodies as Markers of Cancer and Inflammatory Bowel Diseases. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-512173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512173