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New Simple Spectrophotometric Method for the Simultaneous Estimation of Paracetamol and Flupirtine Maleate in Pure and Pharmaceutical Dosage Form
Joint Authors
Source
International Journal of Spectroscopy
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A new, simple, precise, accurate, reproducible, and efficient Vierordt’s method or simultaneous equation method was developed and validated for simultaneous estimation of paracetamol and flupirtine maleate in pure and pharmaceutical dosage form.
The method was based on the measurement of absorbance at two wavelengths 245 nm and 344.5 nm, λmax of paracetamol and flupiritine maleate in 0.1 N HCl correspondingly.
Calibration curves of paracetamol and flupiritine maleate were found to be linear in the concentration ranges of 5–15 μg/mL and 1.53–4.61 μg/mL, respectively, with their correlation coefficient values (R2) 0.999.
LOD and LOQ were 185.90 ng/mL and 563.38 ng/mL for paracetamol and 78.89 ng/mL and 239.06 ng/mL for flupiritine maleate.
In the precision study, the % RSD value was found within limits (RSD<2%).
The percentage recovery at various concentration levels varied from 99.18 to 100.02% for paracetamol and 98.47 to 100.09% for flupiritine maleate confirming that the projected method is accurate.
It could be concluded from the results obtained in the present investigation that this method for simultaneous estimation of paracetamol and flupirtine maleate in pure and tablet dosage form is simple, accurate, precise, and economical.
The proposed method can be applied successfully for the simultaneous estimation of paracetamol and flupiritine maleate in pure and pharmaceutical dosage form.
American Psychological Association (APA)
Giriraj, P.& Sivakkumar, T.. 2014. New Simple Spectrophotometric Method for the Simultaneous Estimation of Paracetamol and Flupirtine Maleate in Pure and Pharmaceutical Dosage Form. International Journal of Spectroscopy،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-512204
Modern Language Association (MLA)
Giriraj, P.& Sivakkumar, T.. New Simple Spectrophotometric Method for the Simultaneous Estimation of Paracetamol and Flupirtine Maleate in Pure and Pharmaceutical Dosage Form. International Journal of Spectroscopy No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-512204
American Medical Association (AMA)
Giriraj, P.& Sivakkumar, T.. New Simple Spectrophotometric Method for the Simultaneous Estimation of Paracetamol and Flupirtine Maleate in Pure and Pharmaceutical Dosage Form. International Journal of Spectroscopy. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-512204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512204