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Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants
Joint Authors
Radonjic, Vidosava
Starcevic, Ana
Dimitrijevic, Ivan
Milovanovic, Srdjan
Starcevic, Branislav
Radojicic, Zoran
Postic, Srdjan
Damjanovic, Aleksandar
Ilankovic, Andrej
Aksić, Milan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
In our study we have hypothesized that volume changes of amygdala, hippocampus, and prefrontal cortex are more pronounced in male posttraumatic stress disorder participants.
Material and Methods.
We have conducted a study of 79 male participants who underwent MRI brain scanning.
PTSD diagnosis was confirmed in 49 participants.
After MRI was taken all scans were software based volume computed and statistically processed.
Results.
We found that left amygdala is the most significant parameter for distinction between PTSD participants and participants without PTSD.
There were no significant differences in volumes of hippocampi and prefrontal cortices.
Roc curve method outlined left amygdala AUC = 0.898 (95% CI = 0.830–0.967) and right amygdala AUC = 0.882 (95% CI = 0.810–0.954) in the group of PTSD participants which makes both variables highly statistically significant.
Conclusion.
The present investigation revealed significant volume decrease of left amygdala in PTSD patients.
Concerning important functions of the amygdala and her neuroanatomical connections with other brain structures, we need to increase number of participants to clarify the correlation between impared amygdala and possible other different brain structures in participants with PTSD.
American Psychological Association (APA)
Starcevic, Ana& Postic, Srdjan& Radojicic, Zoran& Starcevic, Branislav& Milovanovic, Srdjan& Ilankovic, Andrej…[et al.]. 2014. Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-512211
Modern Language Association (MLA)
Starcevic, Ana…[et al.]. Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-512211
American Medical Association (AMA)
Starcevic, Ana& Postic, Srdjan& Radojicic, Zoran& Starcevic, Branislav& Milovanovic, Srdjan& Ilankovic, Andrej…[et al.]. Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-512211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512211