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Expression of Mesothelioma-Related Markers in Meningiomas : An Immunohistochemical Study
Joint Authors
Abdelzaher, Eman
Mohamed Abd Allah, Dina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Meningiomas are common intracranial tumors.
Recently, histogenetic and phenotypic similarities between meningiomas and mesotheliomas have been proposed.
We were interested in whether these similarities are reflected on the immunohistochemical level, which would add new potentially diagnostic markers for meningiomas.
Methods.
The expression of mesothelioma-related markers (D2-40, Calretinin, Keratin 5/6, WT1, and Methotheioma-Ab1) was investigated in 87 cases of meningiomas and compared to EMA expression.
Results.
73.6% of meningioma cases were grade I, 20.7% were grade II, and 5.7% were grade III.
83.9% of meningioma cases were classical and 16.1% had special nonmeningothelial features.
D2-40 was expressed in 37.9% of cases and was significantly restricted to classical meningiomas.
Calretinin and WT1 were negative while Keratin 5/6 and Mesothelioma-Ab1 were weakly expressed in classical variants (5.7% and 3.4%, resp.).
EMA was consistently expressed in all cases.
Its expression was significantly higher than that of mesothelioma-related markers; this held true also when D2-40 expression was considered separately.
Conclusions.
Mesothelioma-related markers are not extensively expressed in meningiomas, a finding that argues against their proposed histogenetic and phenotypic similarities.
Compared to EMA, the significantly lower expression of mesothelioma-related markers and their restricted expression to classical meningioma variants hamper their potential future use as diagnostic markers for meningioma.
American Psychological Association (APA)
Abdelzaher, Eman& Mohamed Abd Allah, Dina. 2014. Expression of Mesothelioma-Related Markers in Meningiomas : An Immunohistochemical Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-512238
Modern Language Association (MLA)
Abdelzaher, Eman& Mohamed Abd Allah, Dina. Expression of Mesothelioma-Related Markers in Meningiomas : An Immunohistochemical Study. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-512238
American Medical Association (AMA)
Abdelzaher, Eman& Mohamed Abd Allah, Dina. Expression of Mesothelioma-Related Markers in Meningiomas : An Immunohistochemical Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-512238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512238