Antiobesity and Hypoglycaemic Effects of Aqueous Extract of Ibervillea sonorae in Mice Fed a High-Fat Diet with Fructose
Joint Authors
Garduño-Siciliano, Leticia
Paniagua-Castro, Norma
Galaviz-Hernández, Carlos
Rivera-Ramírez, Fabiola
Escalona-Cardoso, Gerardo N.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Obesity, type II diabetes, and hyperlipidaemia, which frequently coexist and are strongly associated with oxidative stress, increase the risk of cardiovascular disease.
An increase in carbohydrate intake, especially of fructose, and a high-fat diet are both factors that contribute to the development of these metabolic disorders.
In recent studies carried out in diabetic rats, authors reported that Ibervillea sonorae had hypoglycaemic activity; saponins and monoglycerides present in the plant could be responsible for the effects observed.
In the present study, we determined the effects of an aqueous I.
sonorae extract on a murine model of obesity and hyperglycaemia, induced by a high-calorie diet, and the relationship of these effects with hepatic oxidation.
A high-fat diet over a period of 8 weeks induced weight gain in the mice and increased triglycerides and blood glucose levels.
Simultaneous treatment with I.
sonorae aqueous extracts, at doses of 100, 200, and 400 mg/kg, decreased triglycerides and glycaemia levels, prevented an increase in body weight in a dose-dependent manner, and decreased hepatic lipid oxidation at a dose of 200 mg/kg.
These data suggest that the aqueous extract from I.
sonorae root prevents obesity, dyslipidaemia, and hyperglycaemia induced by a hypercaloric diet; however, high doses may induce toxicity.
American Psychological Association (APA)
Rivera-Ramírez, Fabiola& Escalona-Cardoso, Gerardo N.& Garduño-Siciliano, Leticia& Galaviz-Hernández, Carlos& Paniagua-Castro, Norma. 2011. Antiobesity and Hypoglycaemic Effects of Aqueous Extract of Ibervillea sonorae in Mice Fed a High-Fat Diet with Fructose. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-512242
Modern Language Association (MLA)
Rivera-Ramírez, Fabiola…[et al.]. Antiobesity and Hypoglycaemic Effects of Aqueous Extract of Ibervillea sonorae in Mice Fed a High-Fat Diet with Fructose. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-512242
American Medical Association (AMA)
Rivera-Ramírez, Fabiola& Escalona-Cardoso, Gerardo N.& Garduño-Siciliano, Leticia& Galaviz-Hernández, Carlos& Paniagua-Castro, Norma. Antiobesity and Hypoglycaemic Effects of Aqueous Extract of Ibervillea sonorae in Mice Fed a High-Fat Diet with Fructose. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-512242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512242