![](/images/graphics-bg.png)
Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients
Joint Authors
Jaśkowski, Piotr
Krzanowski, Marcin
Litwin, Jan A.
Gajda, Mariusz
Lis, Grzegorz J.
Sułowicz, Władysław
Janda, Katarzyna
Dumnicka, Paulina
Fedak, Danuta
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The objective of the study was to assess the relationship between selected clinical and biochemical parameters of end stage renal disease (ESRD) patients and arterial calcification.
Materials and Methods.
The study comprised 59 stage 5 chronic kidney disease patients (36 hemodialyzed and 23 predialysis).
The examined parameters included common carotid artery intima-media thickness (CCA-IMT), BMI, incidence of diabetes and impaired fasting glucose (IFG), dyslipidemia, hypertension, and 3-year mortality.
Plasma levels asymmetric dimethylarginine (ADMA), osteopontin (OPN), osteoprotegerin (OPG), and osteocalcin (OC) were also measured.
Fragments of radial artery obtained during creation of hemodialysis access were stained for calcifications using von Kossa method and alizarin red.
Results.
Calcification of radial artery was significantly associated with higher prevalence of IFG and diabetes (P=0.0004) and older age (P=0.003), as well as higher OPG (P=0.014) and ADMA concentrations (P=0.022).
Fasting glucose >5.6 mmol/l (IFG and diabetes) significantly predicted vascular calcification in multiple logistic regression.
The calcification was also associated with higher CCA-IMT (P=0.006) and mortality (P=0.004; OR for death 5.39 [1.20–24.1] after adjustment for dialysis status and age).
Conclusion.
Combination of renal insufficiency and hyperglycemic conditions exerts a synergistic effect on vascular calcification and increases the risk of death.
American Psychological Association (APA)
Janda, Katarzyna& Krzanowski, Marcin& Gajda, Mariusz& Dumnicka, Paulina& Fedak, Danuta& Lis, Grzegorz J.…[et al.]. 2013. Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512248
Modern Language Association (MLA)
Janda, Katarzyna…[et al.]. Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients. International Journal of Endocrinology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-512248
American Medical Association (AMA)
Janda, Katarzyna& Krzanowski, Marcin& Gajda, Mariusz& Dumnicka, Paulina& Fedak, Danuta& Lis, Grzegorz J.…[et al.]. Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512248