Fatal Plasmodium falciparum, Clostridium perfringens, and Candida spp. Coinfections in a Traveler to Haiti

Abstract EN

Malaria is one of the most common causes of febrile illness in travelers.

Coinfections with bacterial, viral, and fungal pathogens may not be suspected unless a patient fails to respond to malaria treatment.

Using novel immunohistochemical and molecular techniques, Plasmodium falciparum, Clostridium perfringens, and Candida spp.

coinfections were confirmed in a German traveler to Haiti.

Plasmodium falciparum-induced ischemia may have increased this patient's susceptibility to C.

perfringens and disseminated candidiasis leading to his death.

When a patient presents with P.

falciparum and shock and is unresponsive to malaria treatment, secondary infections should be suspected to initiate appropriate treatment.