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Possible Treatment Concepts for the Levodopa-Related Hyperhomocysteinemia
Author
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The saga of harmful levodopa (LD) in the treatment of Parkinson's disease (PD) resulted from outcomes of animal—and cell culture studies and the clinical observation of motor complication related to the short half life of LD.
Further aspects of LD long term application, the LD associated homocysteine increase and its emerging consequences on progression, and onset of neuropsychiatric symptoms and of vascular disease are only partially considered.
Therapeutic approaches for this LD-mediated neurotoxic homocysteine increase are vitamin supplementation or LD application with an inhibitor of catechol-O-methyltransferase (COMT).
However, forcing central dopamine metabolism further down the methylation path by central blocking of COMT and MAO-B may reduce oxidative stress and homocysteine levels.
But it may also increase N-methylation of tetrahydroisoquinolines to neurotoxic N-methylated tetrahydroisoquinolines.
These compounds were observed in cerebrospinal fluid and plasma of long term LD-treated PD patients.
Therefore LD application with peripheral COMT inhibition may be safer.
American Psychological Association (APA)
Müller, Thomas. 2009. Possible Treatment Concepts for the Levodopa-Related Hyperhomocysteinemia. Cardiovascular Psychiatry and Neurology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-512299
Modern Language Association (MLA)
Müller, Thomas. Possible Treatment Concepts for the Levodopa-Related Hyperhomocysteinemia. Cardiovascular Psychiatry and Neurology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-512299
American Medical Association (AMA)
Müller, Thomas. Possible Treatment Concepts for the Levodopa-Related Hyperhomocysteinemia. Cardiovascular Psychiatry and Neurology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-512299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512299