Electroacupuncture and Rosiglitazone Combined Therapy as a Means of Treating Insulin Resistance and Type 2 Diabetes Mellitus : A Randomized Controlled Trial
Joint Authors
Chen, Ying-I
Chang, Shih-Liang
Hsu, Tai-Hao
Hung, Pei-Hsiu
Pai, Huei-Chin
Lin, Jaung Geng
Lee, Yu-Chen
Tzeng, Chung-Yuh
Chang, Chin-Hsien
Lin, Rong-Tsung
Tsai, Chin-Chuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aims.
To evaluate the efficacy of rosiglitazone (TZD) and electroacupuncture (EA) combined therapy as a treatment for type 2 diabetes mellitus (T2DM) patients by randomized single-blind placebo controlled clinical trial.
Methods.
A total of 31 newly diagnostic T2DM patients, who fulfilled the study's eligibility criteria, were recruited.
The individuals were randomly assigned into two groups, the control group (TZD, N=15) and the experimental group (TZD + EA, N=16).
Changes in their plasma free fatty acid (FFA), glucose, and insulin levels, together with their homeostasis model assessment (HOMA) indices, were statistically compared before and after treatment.
Hypoglycemic activity (%) was also compared between these two groups.
Results.
There was no significant difference in hypoglycemic activity between the TZD and TZD + EA group.
The effectiveness of the combined therapy seems to derive from an improvement in insulin resistance and a significant lowering of the secreted insulin rather than the effect of TZD alone on T2DM.
The combined treatment had no significant adverse effects.
A lower plasma FFA concentration is likely to be the mechanism that causes this effect.
Conclusion.
This combined therapy seems to suppress endogenous insulin secretion by improving insulin resistance via a mechanism involving a reduction in plasma FFA.
This trial is registered with ClinicalTrials.gov NCT01577095.
American Psychological Association (APA)
Lin, Rong-Tsung& Pai, Huei-Chin& Lee, Yu-Chen& Tzeng, Chung-Yuh& Chang, Chin-Hsien& Hung, Pei-Hsiu…[et al.]. 2013. Electroacupuncture and Rosiglitazone Combined Therapy as a Means of Treating Insulin Resistance and Type 2 Diabetes Mellitus : A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-512308
Modern Language Association (MLA)
Lin, Rong-Tsung…[et al.]. Electroacupuncture and Rosiglitazone Combined Therapy as a Means of Treating Insulin Resistance and Type 2 Diabetes Mellitus : A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-512308
American Medical Association (AMA)
Lin, Rong-Tsung& Pai, Huei-Chin& Lee, Yu-Chen& Tzeng, Chung-Yuh& Chang, Chin-Hsien& Hung, Pei-Hsiu…[et al.]. Electroacupuncture and Rosiglitazone Combined Therapy as a Means of Treating Insulin Resistance and Type 2 Diabetes Mellitus : A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-512308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512308