High-Throughput Sequencing of MicroRNAs in Adenovirus Type 3 Infected Human Laryngeal Epithelial Cells
Joint Authors
Guo, Xiling
Ge, Yiyue
Qi, Yuhua
Shi, Wenting
Cui, Lunbiao
Shan, Yunfeng
Lu, Zuhong
Shan, Jun
Wang, Hua
Tu, Jing
Li, Shuchun
Shi, Zhiyang
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Adenovirus infection can cause various illnesses depending on the infecting serotype, such as gastroenteritis, conjunctivitis, cystitis, and rash illness, but the infection mechanism is still unknown.
MicroRNAs (miRNA) have been reported to play essential roles in cell proliferation, cell differentiation, and pathogenesis of human diseases including viral infections.
We analyzed the miRNA expression profiles from adenovirus type 3 (AD3) infected Human laryngeal epithelial (Hep2) cells using a SOLiD deep sequencing.
492 precursor miRNAs were identified in the AD3 infected Hep2 cells, and 540 precursor miRNAs were identified in the control.
A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control.
The biogenesis of miRNAs has been analyzed, and some of the SOLiD results were confirmed by Quantitative PCR analysis.
The present studies may provide a useful clue for the biological function research into AD3 infection.
American Psychological Association (APA)
Qi, Yuhua& Tu, Jing& Cui, Lunbiao& Guo, Xiling& Shi, Zhiyang& Li, Shuchun…[et al.]. 2010. High-Throughput Sequencing of MicroRNAs in Adenovirus Type 3 Infected Human Laryngeal Epithelial Cells. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-512323
Modern Language Association (MLA)
Qi, Yuhua…[et al.]. High-Throughput Sequencing of MicroRNAs in Adenovirus Type 3 Infected Human Laryngeal Epithelial Cells. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-512323
American Medical Association (AMA)
Qi, Yuhua& Tu, Jing& Cui, Lunbiao& Guo, Xiling& Shi, Zhiyang& Li, Shuchun…[et al.]. High-Throughput Sequencing of MicroRNAs in Adenovirus Type 3 Infected Human Laryngeal Epithelial Cells. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-512323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512323