An Early Morning Sputum Sample Is Necessary for the Diagnosis of Pulmonary Tuberculosis, Even with More Sensitive Techniques : A Prospective Cohort Study among Adolescent TB-Suspects in Uganda
Joint Authors
Wajja, Anne
Nakayita, Germine
Mumbowa, Francis
Waako, James
Verver, Suzanne
Asiimwe, Benon B.
Namaganda, Carolyn
Nassolo, Maria
Mayanja-Kizza, Harriet
Kateete, David P.
Bugumirwa, Eric
Musoke, Philippa
Ssengooba, Willy
Joloba, Moses L.
Mboowa, Gerald
Source
Tuberculosis Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The World Health Organization (WHO) recommends collection of two sputum samples for tuberculosis (TB) diagnosis, with at least one being an early morning (EM) using smear microscopy.
It remains unclear whether this is necessary even when sputum culture is employed.
Here, we determined the diagnostic yield from spot and the incremental yield from the EM sputum sample cultures among TB-suspected adolescents from rural Uganda.
Sputum samples (both spot and early-morning) from 1862 adolescents were cultured by the Lowenstein-Jensen (LJ) and Mycobacterium Growth Indicator Tube (MGIT) methods.
For spot samples, the diagnostic yields for TB were 19.0% and 57.1% with LJ and MGIT, respectively, whereas the incremental yields (not totals) of the early-morning sample were 9.5% and 42.9% (P<0.001) with LJ and MGIT, respectively.
Among TB-suspected adolescents in rural Uganda, the EM sputum culture has a high incremental diagnostic yield.
Therefore, EM sputum in addition to spot sample culture is necessary for improved TB case detection.
American Psychological Association (APA)
Ssengooba, Willy& Kateete, David P.& Wajja, Anne& Bugumirwa, Eric& Mboowa, Gerald& Namaganda, Carolyn…[et al.]. 2012. An Early Morning Sputum Sample Is Necessary for the Diagnosis of Pulmonary Tuberculosis, Even with More Sensitive Techniques : A Prospective Cohort Study among Adolescent TB-Suspects in Uganda. Tuberculosis Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-512328
Modern Language Association (MLA)
Ssengooba, Willy…[et al.]. An Early Morning Sputum Sample Is Necessary for the Diagnosis of Pulmonary Tuberculosis, Even with More Sensitive Techniques : A Prospective Cohort Study among Adolescent TB-Suspects in Uganda. Tuberculosis Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-512328
American Medical Association (AMA)
Ssengooba, Willy& Kateete, David P.& Wajja, Anne& Bugumirwa, Eric& Mboowa, Gerald& Namaganda, Carolyn…[et al.]. An Early Morning Sputum Sample Is Necessary for the Diagnosis of Pulmonary Tuberculosis, Even with More Sensitive Techniques : A Prospective Cohort Study among Adolescent TB-Suspects in Uganda. Tuberculosis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-512328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512328